Predictive energy-efficient motion trajectory optimization of electric vehicles

This work uses a combination of existing and novel methods to optimize the motion trajectory of an electric vehicle in order to improve the energy efficiency and other criteria for a predefined route. The optimization uses a single combined cost function incorporating energy efficiency, travel safety, physical feasibility, and other criteria. Another focus is the optimal behavior beyond the regular optimization horizon

Healthy Placemaking - Revitalizing Springfield\u27s Medical District

Healthy Placemaking - Revitalizing Springfield’s Medical District Healthy Placemaking for the North End Medical District was a community engagement urban design studio for Springfield, MA to propose a new vision for the Medical District as an exemplary model of healthy place-making. WHAT IS HEALTHY PLACE-MAKING? Healthy place-making is a creative process that generates an interconnected mixture of amenities that activate the public realm, creating a livelihood that builds upon sense of place. Urban design strategies consider the ecological relationship between people and the environment in order to provide design interventions that improve the mental, physical, social, and economic wellbeing of inhabitants. Contextually rooted in the history of the area, new and adapted development illustrates environmentally responsible initiatives. EXISTING CONDITIONS 1. No Sense of Place 2. Weak Connections 3. No Mix of Uses and Amenities 4. Unhealthy Environment STUDIO PROCESS AND COMMUNITY ENGAGEMENT Meetings with diverse stakeholders – residents, community leaders, employees in the medical industry- led to a better understanding of assets, challenges and goals from different perspectives. Listening to their ideas was influential for developing the design program. DESIGN STRATEGIES AND OBJECTIVES 1. Enhance the Sense of Place The designs create a sense of place through Landscape Architecture for playing and gathering and the enjoyment of the beauty and healing of plants. 2. Increase Connections The designs create new green connections to work, school and nature in the city. 3. Provide a Balance of Amenities A variety of amenities are introduced into the urban fabric to activate the street life while also stimulating the local economy. 4. Green Infrastructure as a Framework for Public Health Green infrastructure and public health are intrinsically linked: stormwater management, tree canopy, pervious surface cover, and public open space. PLACE-ORIENTED DESIGN PROPOSALS The work explores design proposals for three different places: DESTINATION WASON RIVERSIDE creates two new destinations on the edge of the Connecticut River that engage people and plants, BRIGHTWOOD’S MEDICAL EDGE designs a livable neighborhood with a mix of amenities, gathering places, infill for housing and a remodeled industrial edge to mitigate the impact for residents and to improve the services, and HEALTHY SPACES FOR HEALTHY PEOPLE designs a walkable, green Medical Campus with the framework of the healing landscape

Learning to Coordinate with Anyone

In open multi-agent environments, the agents may encounter unexpected teammates. Classical multi-agent learning approaches train agents that can only coordinate with seen teammates. Recent studies attempted to generate diverse teammates to enhance the generalizable coordination ability, but were restricted by pre-defined teammates. In this work, our aim is to train agents with strong coordination ability by generating teammates that fully cover the teammate policy space, so that agents can coordinate with any teammates. Since the teammate policy space is too huge to be enumerated, we find only dissimilar teammates that are incompatible with controllable agents, which highly reduces the number of teammates that need to be trained with. However, it is hard to determine the number of such incompatible teammates beforehand. We therefore introduce a continual multi-agent learning process, in which the agent learns to coordinate with different teammates until no more incompatible teammates can be found. The above idea is implemented in the proposed Macop (Multi-agent compatible policy learning) algorithm. We conduct experiments in 8 scenarios from 4 environments that have distinct coordination patterns. Experiments show that Macop generates training teammates with much lower compatibility than previous methods. As a result, in all scenarios Macop achieves the best overall coordination ability while never significantly worse than the baselines, showing strong generalization ability

A Comparative Study of Patients’ Attitudes Toward Clinical Research in the United States and Urban and Rural China

As the number of clinical trials conducted in China increases, understanding Chinese attitudes toward clinical research is critical for designing effective and ethical studies. Two survey studies were conducted in 2012 and 2013 to compare patient attitudes toward clinical research and factors affecting research participation in the United States and urban and rural China. We surveyed 525 patients in 2012 (186 US, 186 urban, 153 rural China) and 690 patients in 2013 (412 US, 206 urban, 72 rural China). US patients were more likely to have no concerns regarding research participation than Chinese patients. Most common concerns of US patients were safety, privacy and confidentiality, and time required. Safety was a top concern for many Chinese. Chinese patients, particularly rural Chinese, were more concerned about the likelihood of self‐benefit, and receiving free medical care and financial incentive had greater influence on their participation. Being informed of the freedom to choose whether to participate or to leave a study was less important to Chinese patients. Our study provides important insights into Chinese patients' attitudes toward clinical research and the need to educate them about their rights. These findings help in designing cross‐cultural clinical studies that maximize enrollment while upholding Western ethical standards.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111170/1/cts12254.pd

Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210

Oxidative stress induces endothelial cell apoptosis and promotes atherosclerosis development. MicroRNA-210 (miR-210) is linked with apoptosis in different cell types. This study aimed to investigate the role of miR-210 in human umbilical vein endothelial cells (HUVECs) under oxidative stress and to determine the underlying mechanism. HUVECs were treated with different concentrations of hydrogen peroxide (H2O2), and cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and ATP assay. To evaluate the role of miR-210 in H2O2-mediated apoptosis, gain-and-loss-of-function approaches were used, and the effects on apoptosis and reactive oxygen species (ROS) level were assayed using flow cytometry. Moreover, miR-210 expression was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), and expression of the following apoptosis-related genes was assessed by qRT-PCR and Western blot at the RNA and protein level, respectively: caspase-8-associated protein 2 (CASP8AP2), caspase-8, and caspase-3. The results showed that H2O2 induced apoptosis in HUVECs in a dose-dependent manner and increased miR-210 expression. Overexpression of miR-210 inhibited apoptosis and reduced ROS level in HUVECs treated with H2O2. Furthermore, miR-210 downregulated CASP8AP2 and related downstream caspases at protein level. Thus, under oxidative stress, miR-210 has a prosurvival and antiapoptotic effect on HUVECs by reducing ROS generation and downregulating the CASP8AP2 pathway